Blind Super-Resolution Approach for Exploiting Illumination Variety in Optical-Lattice Illumination Microscopy

Optical-lattice illumination patterns help in pushing high spatial frequency components of the sample into optical transfer function a collection microscope. However, exploiting these high-frequency require precise knowledge if reconstruction approaches similar to structured microscopy are employed. Here, we present an alternate blind approach that can provide super-resolution without requirement extra frames. For this, property temporal fluctuations emissions using “multiple signal classification algorithm” is extended aptly toward fluctuation phase-modulated lattice illuminations for super-resolution. The ability shown sinusoidal and multiperiodic with approximately 3- 6-fold resolution enhancements, respectively, over diffraction limit.